The Girna River rises in Western Ghats at an elevation of 900 m at north latitude of 20°44' and an east longitude of 73°51'The river flows first in an easterly direction up to Jaamda and then turns north. It takes a westerly turn at Nandra to join the Tapi from the left near Nanded. At this point, Tapi has already run for 340 km. Before Joining the Tapi River, the Girna River traverses a distance of 260 km. The drainage area of the river is 10,061 sq. km, which is nearly one-sixth of the total catchment of the Tapi. Girna is the second biggest tributary of Tapi in terms of catchment area. The waters of the Girna are used for irrigation in Nasik and Jalgaon districts. Due to heavy rainfall in the catchment, Girna has important influence on the floods in the Tapi basin.

The basin of the Girna lies on the Deccan Plateau, and its valley has fertile soils which are intensively farmed.